SERPINC1-STAT6 Fusion FISH Probe
The SERPINC1-STAT6 Fusion FISH Probe is used to confirm a fusion of the SERPINC1 and STAT6 genes. The fusion of the SERPINC1 and STAT6 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SERPINC1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| SERPINC1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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SERPINC1 Gene Summary
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
Gene Name: Serpin Family C Member 1
Chromosome: CHR1: 173872941 -173886516
Locus: 1q25.1
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The SERPINC1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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