SENP6-KATNA1 Fusion FISH Probe
The SENP6-KATNA1 Fusion FISH Probe is used to confirm a fusion of the SENP6 and KATNA1 genes. The fusion of the SENP6 and KATNA1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SENP6-KATNA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-RERE | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-REOR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-REGO | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-REGR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-REAQ | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-ORRE | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-OROR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-ORGO | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GORE | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GOOR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GOGO | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GOGR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GRRE | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GROR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GRGO | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GRGR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-AQRE | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-AQOR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-AQGO | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-AQGR | 20 (40 μL) | 200 μL |
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| SENP6-KATNA1-20-AQAQ | 20 (40 μL) | 200 μL |
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KATNA1 Gene Summary
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Gene Name: Katanin Catalytic Subunit A1
Chromosome: CHR6: 149916010 -149969940
Locus: 6q25.1
SENP6 Gene Summary
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Name: SUMO1/sentrin Specific Peptidase 6
Chromosome: CHR6: 76311621 -76427994
Locus: 6q14.1
Gene Diseases
The SENP6 KATNA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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