SENP6-ACACB Fusion FISH Probe
The SENP6-ACACB Fusion FISH Probe is used to confirm a fusion of the SENP6 and ACACB genes. The fusion of the SENP6 and ACACB genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SENP6-ACACB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-RERE | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-REOR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-REGO | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-REGR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-REAQ | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-ORRE | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-OROR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-ORGO | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-ORAQ | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GORE | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GOOR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GOGO | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GOGR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GOAQ | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GRRE | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GROR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GRGO | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GRGR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-GRAQ | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-AQRE | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-AQOR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-AQGO | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-AQGR | 20 (40 μL) | 200 μL |
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| SENP6-ACACB-20-AQAQ | 20 (40 μL) | 200 μL |
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ACACB Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Acetyl-CoA Carboxylase Beta
Chromosome: CHR12: 109577201 -109706030
Locus: 12q24.11
SENP6 Gene Summary
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Name: SUMO1/sentrin Specific Peptidase 6
Chromosome: CHR6: 76311621 -76427994
Locus: 6q14.1
Gene Diseases
The SENP6 ACACB Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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