SENP3-ABR Fusion FISH Probe
The SENP3-ABR Fusion FISH Probe is used to confirm a fusion of the SENP3 and ABR genes. The fusion of the SENP3 and ABR genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SENP3-ABR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-RERE | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-REOR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-REGO | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-REGR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-REAQ | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-ORRE | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-OROR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-ORGO | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-ORAQ | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GORE | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GOOR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GOGO | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GOGR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GOAQ | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GRRE | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GROR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GRGO | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GRGR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-GRAQ | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-AQRE | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-AQOR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-AQGO | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-AQGR | 20 (40 μL) | 200 μL |
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| SENP3-ABR-20-AQAQ | 20 (40 μL) | 200 μL |
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ABR Gene Summary
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Active BCR-related
Chromosome: CHR17: 906758 -1090616
Locus: 17p13.3
SENP3 Gene Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Name: SUMO1/sentrin/SMT3 Specific Peptidase 3
Chromosome: CHR17: 7465308 -7475287
Locus: 17p13.1
Gene Diseases
The SENP3 ABR Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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