SEMA5B-PLS1 Fusion FISH Probe
The SEMA5B-PLS1 Fusion FISH Probe is used to confirm a fusion of the SEMA5B and PLS1 genes. The fusion of the SEMA5B and PLS1 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SEMA5B-PLS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SEMA5B-PLS1-20-AQAQ | 20 (40 μL) | 200 μL |
|
PLS1 Gene Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Gene Name: Plastin 1
Chromosome: CHR3: 142315228 -142432505
Locus: 3q23
SEMA5B Gene Summary
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Semaphorin 5B
Chromosome: CHR3: 122628042 -122746576
Locus: 3q21.1
Gene Diseases
The SEMA5B PLS1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|