SECISBP2-NEDD4L Fusion FISH Probe
The SECISBP2-NEDD4L Fusion FISH Probe is used to confirm a fusion of the SECISBP2 and NEDD4L genes. The fusion of the SECISBP2 and NEDD4L genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SECISBP2-NEDD4L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-RERE | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-REOR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-REGO | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-REGR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-REAQ | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-ORRE | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-OROR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-ORGO | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-ORAQ | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GORE | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GOOR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GOGO | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GOGR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GOAQ | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GRRE | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GROR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GRGO | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GRGR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-GRAQ | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-AQRE | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-AQOR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-AQGO | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-AQGR | 20 (40 μL) | 200 μL |
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| SECISBP2-NEDD4L-20-AQAQ | 20 (40 μL) | 200 μL |
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NEDD4L Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 4-like, E3 Ubiquitin Protein Ligase
Chromosome: CHR18: 55711609 -56068772
Locus: 18q21.31
SECISBP2 Gene Summary
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Gene Name: SECIS Binding Protein 2
Chromosome: CHR9: 91933411 -91974561
Locus: 9q22.2
Gene Diseases
The SECISBP2 NEDD4L Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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