SEC63-PCBP2 Fusion FISH Probe
The SEC63-PCBP2 Fusion FISH Probe is used to confirm a fusion of the SEC63 and PCBP2 genes. The fusion of the SEC63 and PCBP2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC63-PCBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-RERE | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-REOR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-REGO | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-REGR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-OROR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GORE | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GROR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC63-PCBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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PCBP2 Gene Summary
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
Gene Name: Poly(rC) Binding Protein 2
Chromosome: CHR12: 53845885 -53874946
Locus: 12q13.13
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The SEC63 PCBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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