SEC61A1-EIF2AK2 Fusion FISH Probe
The SEC61A1-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the SEC61A1 and EIF2AK2 genes. The fusion of the SEC61A1 and EIF2AK2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC61A1-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC61A1-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
SEC61A1 Gene Summary
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Gene Name: Sec61 Translocon Alpha 1 Subunit
Chromosome: CHR3: 127771211 -127790526
Locus: 3q21.3
Gene Diseases
The SEC61A1 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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