SEC31A-ANAPC10 Fusion FISH Probe
The SEC31A-ANAPC10 Fusion FISH Probe is used to confirm a fusion of the SEC31A and ANAPC10 genes. The fusion of the SEC31A and ANAPC10 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC31A-ANAPC10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-RERE | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-REOR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-REGO | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-REGR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-OROR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GORE | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GROR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC31A-ANAPC10-20-AQAQ | 20 (40 μL) | 200 μL |
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ANAPC10 Gene Summary
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Gene Name: Anaphase Promoting Complex Subunit 10
Chromosome: CHR4: 145916312 -146019368
Locus: 4q31.21
SEC31A Gene Summary
The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: SEC31 Homolog A, COPII Coat Complex Component
Chromosome: CHR4: 83739813 -83812419
Locus: 4q21.22
Gene Diseases
The SEC31A ANAPC10 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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