SEC24D-PLRG1 Fusion FISH Probe
The SEC24D-PLRG1 Fusion FISH Probe is used to confirm a fusion of the SEC24D and PLRG1 genes. The fusion of the SEC24D and PLRG1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC24D-PLRG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-RERE | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-REOR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-REGO | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-REGR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-OROR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GORE | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GROR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC24D-PLRG1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLRG1 Gene Summary
This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Pleiotropic Regulator 1
Chromosome: CHR4: 155456148 -155471585
Locus: 4q31.3
SEC24D Gene Summary
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Mutations in this gene have been associated with Cole-Carpenter syndrome, a disorder affecting bone formation, resulting in craniofacial malformations and bones that break easily. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: SEC24 Homolog D, COPII Coat Complex Component
Chromosome: CHR4: 119643977 -119757326
Locus: 4q26
Gene Diseases
The SEC24D PLRG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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