SEC24D-CFI Fusion FISH Probe
The SEC24D-CFI Fusion FISH Probe is used to confirm a fusion of the SEC24D and CFI genes. The fusion of the SEC24D and CFI genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC24D-CFI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-RERE | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-REOR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-REGO | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-REGR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-OROR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GORE | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GROR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC24D-CFI-20-AQAQ | 20 (40 μL) | 200 μL |
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CFI Gene Summary
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
Gene Name: Complement Factor I
Chromosome: CHR4: 110661847 -110723335
Locus: 4q25
SEC24D Gene Summary
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Mutations in this gene have been associated with Cole-Carpenter syndrome, a disorder affecting bone formation, resulting in craniofacial malformations and bones that break easily. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: SEC24 Homolog D, COPII Coat Complex Component
Chromosome: CHR4: 119643977 -119757326
Locus: 4q26
Gene Diseases
The SEC24D CFI Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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