SEC16A-NOTCH1 Fusion FISH Probe
The SEC16A-NOTCH1 Fusion FISH Probe is used to confirm a fusion of the SEC16A and NOTCH1 genes. The fusion of the SEC16A and NOTCH1 genes has been associated with Thyroid Carcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC16A-NOTCH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-RERE | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-REOR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-REGO | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-REGR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-OROR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GORE | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GROR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC16A-NOTCH1-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH1 Gene Summary
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Gene Name: Notch 1
Chromosome: CHR9: 139388895 -139440238
Locus: 9q34.3
SEC16A Gene Summary
This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Gene Name: SEC16 Homolog A, Endoplasmic Reticulum Export Factor
Chromosome: CHR9: 139334547 -139377507
Locus: 9q34.3
Gene Diseases
The SEC16A NOTCH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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