SEC14L1-SPOP Fusion FISH Probe
The SEC14L1-SPOP Fusion FISH Probe is used to confirm a fusion of the SEC14L1 and SPOP genes. The fusion of the SEC14L1 and SPOP genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC14L1-SPOP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-RERE | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-REOR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-REGO | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-REGR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-OROR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GORE | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GROR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC14L1-SPOP-20-AQAQ | 20 (40 μL) | 200 μL |
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SEC14L1 Gene Summary
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
Gene Name: SEC14 Like Lipid Binding 1
Chromosome: CHR17: 75084724 -75213181
Locus: 17q25.2-q25.3
SPOP Gene Summary
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Speckle Type BTB/POZ Protein
Chromosome: CHR17: 47676245 -47755525
Locus: 17q21.33
Gene Diseases
The SEC14L1 SPOP Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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