SEC11A-VPS33B Fusion FISH Probe
The SEC11A-VPS33B Fusion FISH Probe is used to confirm a fusion of the SEC11A and VPS33B genes. The fusion of the SEC11A and VPS33B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC11A-VPS33B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-RERE | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-REOR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-REGO | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-REGR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-OROR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GORE | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GROR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC11A-VPS33B-20-AQAQ | 20 (40 μL) | 200 μL |
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SEC11A Gene Summary
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Gene Name: SEC11 Homolog A, Signal Peptidase Complex Subunit
Chromosome: CHR15: 85212774 -85259674
Locus: 15q25.2-q25.3
VPS33B Gene Summary
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: VPS33B, Late Endosome And Lysosome Associated
Chromosome: CHR15: 91541773 -91565833
Locus: 15q26.1
Gene Diseases
The SEC11A VPS33B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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