SDHB-PLN Fusion FISH Probe
The SDHB-PLN Fusion FISH Probe is used to confirm a fusion of the SDHB and PLN genes. The fusion of the SDHB and PLN genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SDHB-PLN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-RERE | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-REOR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-REGO | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-REGR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-REAQ | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-ORRE | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-OROR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-ORGO | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-ORAQ | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GORE | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GOOR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GOGO | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GOGR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GOAQ | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GRRE | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GROR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GRGO | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GRGR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-GRAQ | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-AQRE | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-AQOR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-AQGO | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-AQGR | 20 (40 μL) | 200 μL |
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| SDHB-PLN-20-AQAQ | 20 (40 μL) | 200 μL |
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PLN Gene Summary
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Gene Name: Phospholamban
Chromosome: CHR6: 118869441 -118881587
Locus: 6q22.31
SDHB Gene Summary
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Succinate Dehydrogenase Complex Iron Sulfur Subunit B
Chromosome: CHR1: 17345224 -17380665
Locus: 1p36.13
Gene Diseases
The SDHB PLN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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