SDC1-PLAT Fusion FISH Probe
The SDC1-PLAT Fusion FISH Probe is used to confirm a fusion of the SDC1 and PLAT genes. The fusion of the SDC1 and PLAT genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SDC1-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| SDC1-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
SDC1 Gene Summary
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Syndecan 1
Chromosome: CHR2: 20400557 -20425194
Locus: 2p24.1
Gene Diseases
The SDC1 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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