SCYL3-KIFAP3 Fusion FISH Probe
The SCYL3-KIFAP3 Fusion FISH Probe is used to confirm a fusion of the SCYL3 and KIFAP3 genes. The fusion of the SCYL3 and KIFAP3 genes has been associated with Lung Squamous Cell Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCYL3-KIFAP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-RERE | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-REOR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-REGO | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-REGR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-REAQ | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-ORRE | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-OROR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-ORGO | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GORE | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GOOR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GOGO | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GOGR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GRRE | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GROR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GRGO | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GRGR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-AQRE | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-AQOR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-AQGO | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-AQGR | 20 (40 μL) | 200 μL |
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| SCYL3-KIFAP3-20-AQAQ | 20 (40 μL) | 200 μL |
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KIFAP3 Gene Summary
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: Kinesin Associated Protein 3
Chromosome: CHR1: 169890469 -170043879
Locus: 1q24.2
SCYL3 Gene Summary
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Gene Name: SCY1 Like Pseudokinase 3
Chromosome: CHR1: 169821803 -169863076
Locus: 1q24.2
Gene Diseases
The SCYL3 KIFAP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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