SCYL2-ANKS1B Fusion FISH Probe
The SCYL2-ANKS1B Fusion FISH Probe is used to confirm a fusion of the SCYL2 and ANKS1B genes. The fusion of the SCYL2 and ANKS1B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCYL2-ANKS1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-RERE | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-REOR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-REGO | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-REGR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-REAQ | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-ORRE | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-OROR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-ORGO | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GORE | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GOOR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GOGO | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GOGR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GRRE | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GROR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GRGO | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GRGR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-AQRE | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-AQOR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-AQGO | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-AQGR | 20 (40 μL) | 200 μL |
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| SCYL2-ANKS1B-20-AQAQ | 20 (40 μL) | 200 μL |
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SCYL2 Gene Summary
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: SCY1 Like Pseudokinase 2
Chromosome: CHR12: 100661548 -100733914
Locus: 12q23.1
ANKS1B Gene Summary
This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1B
Chromosome: CHR12: 99128568 -100378432
Locus: 12q23.1
Gene Diseases
The SCYL2 ANKS1B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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