SCUBE3-ANKS1A Fusion FISH Probe
The SCUBE3-ANKS1A Fusion FISH Probe is used to confirm a fusion of the SCUBE3 and ANKS1A genes. The fusion of the SCUBE3 and ANKS1A genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCUBE3-ANKS1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-RERE | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-REOR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-REGO | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-REGR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-REAQ | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-ORRE | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-OROR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-ORGO | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GORE | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GOOR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GOGO | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GOGR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GRRE | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GROR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GRGO | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GRGR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-AQRE | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-AQOR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-AQGO | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-AQGR | 20 (40 μL) | 200 μL |
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| SCUBE3-ANKS1A-20-AQAQ | 20 (40 μL) | 200 μL |
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ANKS1A Gene Summary
The Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A (ANKS1A) gene is located on chr6 :34857037-35059190 at 6p21.31.
Gene Name: Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A
Chromosome: CHR6: 34857037 -35059190
Locus: 6p21.31
SCUBE3 Gene Summary
This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Signal Peptide, CUB Domain And EGF Like Domain Containing 3
Chromosome: CHR6: 35182189 -35218609
Locus: 6p21.31
Gene Diseases
The SCUBE3 ANKS1A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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