SCN8A-KCNC2 Fusion FISH Probe
The SCN8A-KCNC2 Fusion FISH Probe is used to confirm a fusion of the SCN8A and KCNC2 genes. The fusion of the SCN8A and KCNC2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCN8A-KCNC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-RERE | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-REOR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-REGO | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-REGR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-REAQ | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-ORRE | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-OROR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-ORGO | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GORE | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GOOR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GOGO | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GOGR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GRRE | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GROR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GRGO | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GRGR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-AQRE | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-AQOR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-AQGO | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-AQGR | 20 (40 μL) | 200 μL |
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| SCN8A-KCNC2-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNC2 Gene Summary
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: Potassium Voltage-gated Channel Subfamily C Member 2
Chromosome: CHR12: 75433895 -75603511
Locus: 12q21.1
SCN8A Gene Summary
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Sodium Voltage-gated Channel Alpha Subunit 8
Chromosome: CHR12: 51985019 -52202299
Locus: 12q13.13
Gene Diseases
The SCN8A KCNC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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