SCLY-RAMP1 Fusion FISH Probe
The SCLY-RAMP1 Fusion FISH Probe is used to confirm a fusion of the SCLY and RAMP1 genes. The fusion of the SCLY and RAMP1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCLY-RAMP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-RERE | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-REOR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-REGO | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-REGR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-REAQ | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-ORRE | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-OROR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-ORGO | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GORE | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GOOR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GOGO | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GOGR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GRRE | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GROR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GRGO | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GRGR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-AQRE | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-AQOR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-AQGO | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-AQGR | 20 (40 μL) | 200 μL |
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| SCLY-RAMP1-20-AQAQ | 20 (40 μL) | 200 μL |
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RAMP1 Gene Summary
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Gene Name: Receptor Activity Modifying Protein 1
Chromosome: CHR2: 238768186 -238820755
Locus: 2q37.3
SCLY Gene Summary
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Gene Name: Selenocysteine Lyase
Chromosome: CHR2: 238969564 -239008054
Locus: 2q37.3
Gene Diseases
The SCLY RAMP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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