SCGB1D2-FADS2 Fusion FISH Probe
The SCGB1D2-FADS2 Fusion FISH Probe is used to confirm a fusion of the SCGB1D2 and FADS2 genes. The fusion of the SCGB1D2 and FADS2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCGB1D2-FADS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-RERE | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-REOR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-REGO | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-REGR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-REAQ | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-ORRE | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-OROR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-ORGO | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GORE | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GOOR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GOGO | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GOGR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GRRE | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GROR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GRGO | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GRGR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-AQRE | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-AQOR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-AQGO | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-AQGR | 20 (40 μL) | 200 μL |
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| SCGB1D2-FADS2-20-AQAQ | 20 (40 μL) | 200 μL |
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FADS2 Gene Summary
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Name: Fatty Acid Desaturase 2
Chromosome: CHR11: 61595712 -61634825
Locus: 11q12.2
SCGB1D2 Gene Summary
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]
Gene Name: Secretoglobin Family 1D Member 2
Chromosome: CHR11: 62009723 -62012280
Locus: 11q12.3
Gene Diseases
The SCGB1D2 FADS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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