SCG2-PTGS1 Fusion FISH Probe
The SCG2-PTGS1 Fusion FISH Probe is used to confirm a fusion of the SCG2 and PTGS1 genes. The fusion of the SCG2 and PTGS1 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCG2-PTGS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-RERE | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-REOR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-REGO | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-REGR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-REAQ | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-ORRE | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-OROR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-ORGO | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GORE | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GOOR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GOGO | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GOGR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GRRE | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GROR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GRGO | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GRGR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-AQRE | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-AQOR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-AQGO | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-AQGR | 20 (40 μL) | 200 μL |
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| SCG2-PTGS1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTGS1 Gene Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Prostaglandin-endoperoxide Synthase 1
Chromosome: CHR9: 125133228 -125157981
Locus: 9q33.2
SCG2 Gene Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Gene Name: Secretogranin II
Chromosome: CHR2: 224461657 -224467217
Locus: 2q36.1
Gene Diseases
The SCG2 PTGS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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