SCD5-STAP1 Fusion FISH Probe
The SCD5-STAP1 Fusion FISH Probe is used to confirm a fusion of the SCD5 and STAP1 genes. The fusion of the SCD5 and STAP1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SCD5-STAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-RERE | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-REOR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-REGO | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-REGR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-OROR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GORE | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GROR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| SCD5-STAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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STAP1 Gene Summary
The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Signal Transducing Adaptor Family Member 1
Chromosome: CHR4: 68424445 -68472616
Locus: 4q13.2
SCD5 Gene Summary
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
Gene Name: Stearoyl-CoA Desaturase 5
Chromosome: CHR4: 83550689 -83720010
Locus: 4q21.22
Gene Diseases
The SCD5 STAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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