SBNO2-RAP1GAP Fusion FISH Probe
The SBNO2-RAP1GAP Fusion FISH Probe is used to confirm a fusion of the SBNO2 and RAP1GAP genes. The fusion of the SBNO2 and RAP1GAP genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SBNO2-RAP1GAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-RERE | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-REOR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-REGO | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-REGR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-REAQ | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-ORRE | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-OROR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-ORGO | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-ORAQ | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GORE | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GOOR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GOGO | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GOGR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GOAQ | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GRRE | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GROR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GRGO | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GRGR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-GRAQ | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-AQRE | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-AQOR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-AQGO | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-AQGR | 20 (40 μL) | 200 μL |
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| SBNO2-RAP1GAP-20-AQAQ | 20 (40 μL) | 200 μL |
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RAP1GAP Gene Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Name: RAP1 GTPase Activating Protein
Chromosome: CHR1: 21922707 -21995856
Locus: 1p36.12
SBNO2 Gene Summary
The Strawberry Notch Homolog 2 (SBNO2) gene is located on chr19 :1107632-1174282 at 19p13.3.
Gene Name: Strawberry Notch Homolog 2
Chromosome: CHR19: 1107632 -1174282
Locus: 19p13.3
Gene Diseases
The SBNO2 RAP1GAP Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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