SBNO2-CLEC4M Fusion FISH Probe
The SBNO2-CLEC4M Fusion FISH Probe is used to confirm a fusion of the SBNO2 and CLEC4M genes. The fusion of the SBNO2 and CLEC4M genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SBNO2-CLEC4M-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SBNO2-CLEC4M-20-AQAQ | 20 (40 μL) | 200 μL |
|
CLEC4M Gene Summary
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Gene Name: C-type Lectin Domain Family 4 Member M
Chromosome: CHR19: 7828034 -7834491
Locus: 19p13.2
SBNO2 Gene Summary
The Strawberry Notch Homolog 2 (SBNO2) gene is located on chr19 :1107632-1174282 at 19p13.3.
Gene Name: Strawberry Notch Homolog 2
Chromosome: CHR19: 1107632 -1174282
Locus: 19p13.3
Gene Diseases
The SBNO2 CLEC4M Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|