SBF2-MRVI1 Fusion FISH Probe
The SBF2-MRVI1 Fusion FISH Probe is used to confirm a fusion of the SBF2 and MRVI1 genes. The fusion of the SBF2 and MRVI1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SBF2-MRVI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-RERE | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-REOR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-REGO | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-REGR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-REAQ | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-ORRE | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-OROR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-ORGO | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GORE | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GOOR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GOGO | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GOGR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GRRE | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GROR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GRGO | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GRGR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-AQRE | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-AQOR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-AQGO | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-AQGR | 20 (40 μL) | 200 μL |
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| SBF2-MRVI1-20-AQAQ | 20 (40 μL) | 200 μL |
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MRVI1 Gene Summary
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
Gene Name: Murine Retrovirus Integration Site 1 Homolog
Chromosome: CHR11: 10594637 -10715535
Locus: 11p15.4
SBF2 Gene Summary
This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. [provided by RefSeq, Jul 2008]
Gene Name: SET Binding Factor 2
Chromosome: CHR11: 9800213 -10315754
Locus: 11p15.4
Gene Diseases
The SBF2 MRVI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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