SASH1-PLN Fusion FISH Probe
The SASH1-PLN Fusion FISH Probe is used to confirm a fusion of the SASH1 and PLN genes. The fusion of the SASH1 and PLN genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SASH1-PLN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-RERE | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-REOR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-REGO | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-REGR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-REAQ | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-ORRE | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-OROR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-ORGO | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-ORAQ | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GORE | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GOOR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GOGO | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GOGR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GOAQ | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GRRE | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GROR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GRGO | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GRGR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-GRAQ | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-AQRE | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-AQOR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-AQGO | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-AQGR | 20 (40 μL) | 200 μL |
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| SASH1-PLN-20-AQAQ | 20 (40 μL) | 200 μL |
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PLN Gene Summary
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Gene Name: Phospholamban
Chromosome: CHR6: 118869441 -118881587
Locus: 6q22.31
SASH1 Gene Summary
This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]
Gene Name: SAM And SH3 Domain Containing 1
Chromosome: CHR6: 148663728 -148873184
Locus: 6q24.3-q25.1
Gene Diseases
The SASH1 PLN Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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