SAMM50-TXNRD2 Fusion FISH Probe
The SAMM50-TXNRD2 Fusion FISH Probe is used to confirm a fusion of the SAMM50 and TXNRD2 genes. The fusion of the SAMM50 and TXNRD2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SAMM50-TXNRD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-RERE | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-REOR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-REGO | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-REGR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-REAQ | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-ORRE | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-OROR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-ORGO | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GORE | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GOOR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GOGO | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GOGR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GRRE | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GROR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GRGO | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GRGR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-AQRE | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-AQOR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-AQGO | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-AQGR | 20 (40 μL) | 200 μL |
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| SAMM50-TXNRD2-20-AQAQ | 20 (40 μL) | 200 μL |
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TXNRD2 Gene Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: Thioredoxin Reductase 2
Chromosome: CHR22: 19863039 -19929359
Locus: 22q11.21
SAMM50 Gene Summary
This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]
Gene Name: SAMM50 Sorting And Assembly Machinery Component
Chromosome: CHR22: 44351260 -44392412
Locus: 22q13.31
Gene Diseases
The SAMM50 TXNRD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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