SAFB-RFX2 Fusion FISH Probe
The SAFB-RFX2 Fusion FISH Probe is used to confirm a fusion of the SAFB and RFX2 genes. The fusion of the SAFB and RFX2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SAFB-RFX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-RERE | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-REOR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-REGO | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-REGR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-REAQ | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-ORRE | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-OROR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-ORGO | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GORE | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GOOR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GOGO | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GOGR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GRRE | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GROR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GRGO | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GRGR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-AQRE | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-AQOR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-AQGO | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-AQGR | 20 (40 μL) | 200 μL |
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| SAFB-RFX2-20-AQAQ | 20 (40 μL) | 200 μL |
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RFX2 Gene Summary
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]
Gene Name: Regulatory Factor X2
Chromosome: CHR19: 5993174 -6110664
Locus: 19p13.3
SAFB Gene Summary
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Gene Name: Scaffold Attachment Factor B
Chromosome: CHR19: 5623045 -5668489
Locus: 19p13.3
Gene Diseases
The SAFB RFX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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