SAE1-RPA2 Fusion FISH Probe
The SAE1-RPA2 Fusion FISH Probe is used to confirm a fusion of the SAE1 and RPA2 genes. The fusion of the SAE1 and RPA2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SAE1-RPA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-RERE | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-REOR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-REGO | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-REGR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-REAQ | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-ORRE | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-OROR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-ORGO | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GORE | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GOOR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GOGO | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GOGR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GRRE | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GROR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GRGO | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GRGR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-AQRE | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-AQOR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-AQGO | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-AQGR | 20 (40 μL) | 200 μL |
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| SAE1-RPA2-20-AQAQ | 20 (40 μL) | 200 μL |
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RPA2 Gene Summary
This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]
Gene Name: Replication Protein A2
Chromosome: CHR1: 28218048 -28241236
Locus: 1p35.3
SAE1 Gene Summary
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Gene Name: SUMO1 Activating Enzyme Subunit 1
Chromosome: CHR19: 47634079 -47713893
Locus: 19q13.32
Gene Diseases
The SAE1 RPA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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