SAE1-BAX Fusion FISH Probe
The SAE1-BAX Fusion FISH Probe is used to confirm a fusion of the SAE1 and BAX genes. The fusion of the SAE1 and BAX genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SAE1-BAX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-RERE | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-REOR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-REGO | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-REGR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-REAQ | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-ORRE | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-OROR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-ORGO | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-ORAQ | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GORE | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GOOR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GOGO | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GOGR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GOAQ | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GRRE | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GROR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GRGO | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GRGR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-GRAQ | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-AQRE | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-AQOR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-AQGO | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-AQGR | 20 (40 μL) | 200 μL |
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| SAE1-BAX-20-AQAQ | 20 (40 μL) | 200 μL |
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BAX Gene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCL2 Associated X, Apoptosis Regulator
Chromosome: CHR19: 49458116 -49465055
Locus: 19q13.33
SAE1 Gene Summary
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Gene Name: SUMO1 Activating Enzyme Subunit 1
Chromosome: CHR19: 47634079 -47713893
Locus: 19q13.32
Gene Diseases
The SAE1 BAX Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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