SACS-MIPEP Fusion FISH Probe
The SACS-MIPEP Fusion FISH Probe is used to confirm a fusion of the SACS and MIPEP genes. The fusion of the SACS and MIPEP genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SACS-MIPEP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SACS-MIPEP-20-AQAQ | 20 (40 μL) | 200 μL |
|
MIPEP Gene Summary
The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Intermediate Peptidase
Chromosome: CHR13: 24304327 -24463587
Locus: 13q12.12
SACS Gene Summary
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Sacsin Molecular Chaperone
Chromosome: CHR13: 23902964 -24007841
Locus: 13q12.12
Gene Diseases
The SACS MIPEP Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|