S100A6-CD40 Fusion FISH Probe
The S100A6-CD40 Fusion FISH Probe is used to confirm a fusion of the S100A6 and CD40 genes. The fusion of the S100A6 and CD40 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| S100A6-CD40-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-RERE | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-REOR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-REGO | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-REGR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-REAQ | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-ORRE | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-OROR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-ORGO | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-ORAQ | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GORE | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GOOR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GOGO | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GOGR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GOAQ | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GRRE | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GROR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GRGO | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GRGR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-GRAQ | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-AQRE | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-AQOR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-AQGO | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-AQGR | 20 (40 μL) | 200 μL |
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| S100A6-CD40-20-AQAQ | 20 (40 μL) | 200 μL |
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CD40 Gene Summary
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Gene Name: CD40 Molecule
Chromosome: CHR20: 44746905 -44758384
Locus: 20q13.12
S100A6 Gene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Gene Name: S100 Calcium Binding Protein A6
Chromosome: CHR1: 153507075 -153508717
Locus: 1q21.3
Gene Diseases
The S100A6 CD40 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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