RUNX2-MAX Fusion FISH Probe
The RUNX2-MAX Fusion FISH Probe is used to confirm a fusion of the RUNX2 and MAX genes. The fusion of the RUNX2 and MAX genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RUNX2-MAX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-RERE | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-REOR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-REGO | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-REGR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-REAQ | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-ORRE | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-OROR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-ORGO | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-ORAQ | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GORE | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GOOR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GOGO | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GOGR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GOAQ | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GRRE | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GROR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GRGO | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GRGR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-GRAQ | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-AQRE | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-AQOR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-AQGO | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-AQGR | 20 (40 μL) | 200 μL |
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| RUNX2-MAX-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX2 Gene Summary
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]
Gene Name: Runt Related Transcription Factor 2
Chromosome: CHR6: 45296053 -45518819
Locus: 6p21.1
MAX Gene Summary
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Name: MYC Associated Factor X
Chromosome: CHR14: 65472891 -65569227
Locus: 14q23.3
Gene Diseases
The RUNX2 MAX Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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