RUNX1-RUNX1T1 Fusion FISH Probe
The RUNX1-RUNX1T1 Fusion FISH Probe is used to confirm a fusion of the RUNX1 and RUNX1T1 genes. The fusion of the RUNX1 and RUNX1T1 genes has been associated with Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, and Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RUNX1-RUNX1T1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-RERE | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-REOR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-REGO | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-REGR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-REAQ | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-ORRE | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-OROR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-ORGO | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GORE | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GOOR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GOGO | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GOGR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GRRE | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GROR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GRGO | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GRGR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-AQRE | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-AQOR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-AQGO | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-AQGR | 20 (40 μL) | 200 μL |
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| RUNX1-RUNX1T1-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX1 Gene Summary
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Runt Related Transcription Factor 1
Chromosome: CHR21: 36160097 -36421595
Locus: 21q22.12
RUNX1T1 Gene Summary
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Name: RUNX1 Translocation Partner 1
Chromosome: CHR8: 92967194 -93115454
Locus: 8q21.3
Gene Diseases
The RUNX1 RUNX1T1 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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