RUNX1-PROS1 Fusion FISH Probe
The RUNX1-PROS1 Fusion FISH Probe is used to confirm a fusion of the RUNX1 and PROS1 genes. The fusion of the RUNX1 and PROS1 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RUNX1-PROS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-RERE | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-REOR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-REGO | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-REGR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-REAQ | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-ORRE | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-OROR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-ORGO | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GORE | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GOOR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GOGO | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GOGR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GRRE | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GROR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GRGO | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GRGR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-AQRE | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-AQOR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-AQGO | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-AQGR | 20 (40 μL) | 200 μL |
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| RUNX1-PROS1-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX1 Gene Summary
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Runt Related Transcription Factor 1
Chromosome: CHR21: 36160097 -36421595
Locus: 21q22.12
PROS1 Gene Summary
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Gene Name: Protein S
Chromosome: CHR3: 93591880 -93692934
Locus: 3q11.1
Gene Diseases
The RUNX1 PROS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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