RUNX1-IFNAR1 Fusion FISH Probe
The RUNX1-IFNAR1 Fusion FISH Probe is used to confirm a fusion of the RUNX1 and IFNAR1 genes. The fusion of the RUNX1 and IFNAR1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RUNX1-IFNAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-RERE | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-REOR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-REGO | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-REGR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-OROR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GORE | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GROR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| RUNX1-IFNAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX1 Gene Summary
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Runt Related Transcription Factor 1
Chromosome: CHR21: 36160097 -36421595
Locus: 21q22.12
IFNAR1 Gene Summary
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
Gene Name: Interferon Alpha And Beta Receptor Subunit 1
Chromosome: CHR21: 34697213 -34732128
Locus: 21q22.11
Gene Diseases
The RUNX1 IFNAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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