RTTN-MAPK4 Fusion FISH Probe
The RTTN-MAPK4 Fusion FISH Probe is used to confirm a fusion of the RTTN and MAPK4 genes. The fusion of the RTTN and MAPK4 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RTTN-MAPK4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-RERE | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-REOR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-REGO | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-REGR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-REAQ | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-ORRE | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-OROR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-ORGO | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-ORAQ | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GORE | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GOOR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GOGO | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GOGR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GOAQ | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GRRE | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GROR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GRGO | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GRGR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-GRAQ | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-AQRE | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-AQOR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-AQGO | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-AQGR | 20 (40 μL) | 200 μL |
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| RTTN-MAPK4-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK4 Gene Summary
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Mitogen-activated Protein Kinase 4
Chromosome: CHR18: 48086483 -48258196
Locus: 18q21.1-q21.2
RTTN Gene Summary
This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]
Gene Name: Rotatin
Chromosome: CHR18: 67671042 -67872962
Locus: 18q22.2
Gene Diseases
The RTTN MAPK4 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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