RSF1-ARRB1 Fusion FISH Probe
The RSF1-ARRB1 Fusion FISH Probe is used to confirm a fusion of the RSF1 and ARRB1 genes. The fusion of the RSF1 and ARRB1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RSF1-ARRB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-RERE | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-REOR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-REGO | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-REGR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-REAQ | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-ORRE | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-OROR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-ORGO | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GORE | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GOOR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GOGO | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GOGR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GRRE | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GROR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GRGO | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GRGR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-AQRE | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-AQOR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-AQGO | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-AQGR | 20 (40 μL) | 200 μL |
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| RSF1-ARRB1-20-AQAQ | 20 (40 μL) | 200 μL |
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ARRB1 Gene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Name: Arrestin Beta 1
Chromosome: CHR11: 74971165 -75062875
Locus: 11q13.4
RSF1 Gene Summary
This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Gene Name: Remodeling And Spacing Factor 1
Chromosome: CHR11: 77377273 -77531880
Locus: 11q14.1
Gene Diseases
The RSF1 ARRB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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