RREB1-WRAP53 Fusion FISH Probe
The RREB1-WRAP53 Fusion FISH Probe is used to confirm a fusion of the RREB1 and WRAP53 genes. The fusion of the RREB1 and WRAP53 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RREB1-WRAP53-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-RERE | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-REOR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-REGO | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-REGR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-REAQ | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-ORRE | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-OROR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-ORGO | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-ORAQ | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GORE | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GOOR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GOGO | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GOGR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GOAQ | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GRRE | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GROR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GRGO | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GRGR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-GRAQ | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-AQRE | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-AQOR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-AQGO | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-AQGR | 20 (40 μL) | 200 μL |
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| RREB1-WRAP53-20-AQAQ | 20 (40 μL) | 200 μL |
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RREB1 Gene Summary
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Name: Ras Responsive Element Binding Protein 1
Chromosome: CHR6: 7107829 -7252213
Locus: 6p24.3
WRAP53 Gene Summary
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: WD Repeat Containing Antisense To TP53
Chromosome: CHR17: 7589388 -7606820
Locus: 17p13.1
Gene Diseases
The RREB1 WRAP53 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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