RREB1-F13A1 Fusion FISH Probe
The RREB1-F13A1 Fusion FISH Probe is used to confirm a fusion of the RREB1 and F13A1 genes. The fusion of the RREB1 and F13A1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RREB1-F13A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-RERE | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-REOR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-REGO | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-REGR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-REAQ | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-ORRE | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-OROR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-ORGO | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GORE | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GOOR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GOGO | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GOGR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GRRE | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GROR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GRGO | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GRGR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-AQRE | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-AQOR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-AQGO | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-AQGR | 20 (40 μL) | 200 μL |
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| RREB1-F13A1-20-AQAQ | 20 (40 μL) | 200 μL |
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F13A1 Gene Summary
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Gene Name: Coagulation Factor XIII A Chain
Chromosome: CHR6: 6144310 -6320924
Locus: 6p25.1
RREB1 Gene Summary
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Name: Ras Responsive Element Binding Protein 1
Chromosome: CHR6: 7107829 -7252213
Locus: 6p24.3
Gene Diseases
The RREB1 F13A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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