RRBP1-ARFGEF2 Fusion FISH Probe
The RRBP1-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the RRBP1 and ARFGEF2 genes. The fusion of the RRBP1 and ARFGEF2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RRBP1-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| RRBP1-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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RRBP1 Gene Summary
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]
Gene Name: Ribosome Binding Protein 1
Chromosome: CHR20: 17594322 -17662928
Locus: 20p12.1
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The RRBP1 ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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