RRAS2-FHIT Fusion FISH Probe
The RRAS2-FHIT Fusion FISH Probe is used to confirm a fusion of the RRAS2 and FHIT genes. The fusion of the RRAS2 and FHIT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RRAS2-FHIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-RERE | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-REOR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-REGO | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-REGR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-REAQ | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-ORRE | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-OROR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-ORGO | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GORE | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GOOR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GOGO | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GOGR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GRRE | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GROR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GRGO | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GRGR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-AQRE | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-AQOR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-AQGO | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-AQGR | 20 (40 μL) | 200 μL |
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| RRAS2-FHIT-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
RRAS2 Gene Summary
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Name: RAS Related 2
Chromosome: CHR11: 14299465 -14386052
Locus: 11p15.2
Gene Diseases
The RRAS2 FHIT Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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