RPTOR-GPC3 Fusion FISH Probe
The RPTOR-GPC3 Fusion FISH Probe is used to confirm a fusion of the RPTOR and GPC3 genes. The fusion of the RPTOR and GPC3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPTOR-GPC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-RERE | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-REOR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-REGO | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-REGR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-REAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-ORRE | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-OROR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-ORGO | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GORE | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GOOR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GOGO | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GOGR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GRRE | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GROR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GRGO | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GRGR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-AQRE | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-AQOR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-AQGO | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-AQGR | 20 (40 μL) | 200 μL |
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| RPTOR-GPC3-20-AQAQ | 20 (40 μL) | 200 μL |
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GPC3 Gene Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Name: Glypican 3
Chromosome: CHRX: 132669775 -133119673
Locus: Xq26.2
RPTOR Gene Summary
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Regulatory Associated Protein Of MTOR Complex 1
Chromosome: CHR17: 78518624 -78940173
Locus: 17q25.3
Gene Diseases
The RPTOR GPC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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