RPTOR-GAA Fusion FISH Probe
The RPTOR-GAA Fusion FISH Probe is used to confirm a fusion of the RPTOR and GAA genes. The fusion of the RPTOR and GAA genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPTOR-GAA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-RERE | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-REOR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-REGO | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-REGR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-REAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-ORRE | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-OROR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-ORGO | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GORE | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GOOR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GOGO | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GOGR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GRRE | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GROR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GRGO | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GRGR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-AQRE | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-AQOR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-AQGO | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-AQGR | 20 (40 μL) | 200 μL |
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| RPTOR-GAA-20-AQAQ | 20 (40 μL) | 200 μL |
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GAA Gene Summary
This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. The encoded preproprotein is proteolytically processed to generate multiple intermediate forms and the mature form of the enzyme. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Glucosidase Alpha, Acid
Chromosome: CHR17: 78075354 -78093679
Locus: 17q25.3
RPTOR Gene Summary
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Regulatory Associated Protein Of MTOR Complex 1
Chromosome: CHR17: 78518624 -78940173
Locus: 17q25.3
Gene Diseases
The RPTOR GAA Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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