RPS6KA3-BMX Fusion FISH Probe
The RPS6KA3-BMX Fusion FISH Probe is used to confirm a fusion of the RPS6KA3 and BMX genes. The fusion of the RPS6KA3 and BMX genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPS6KA3-BMX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-RERE | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-REOR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-REGO | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-REGR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-REAQ | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-ORRE | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-OROR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-ORGO | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GORE | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GOOR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GOGO | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GOGR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GRRE | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GROR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GRGO | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GRGR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-AQRE | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-AQOR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-AQGO | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-AQGR | 20 (40 μL) | 200 μL |
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| RPS6KA3-BMX-20-AQAQ | 20 (40 μL) | 200 μL |
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BMX Gene Summary
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Gene Name: BMX Non-receptor Tyrosine Kinase
Chromosome: CHRX: 15518899 -15574652
Locus: Xp22.2
RPS6KA3 Gene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein S6 Kinase A3
Chromosome: CHRX: 20168028 -20284750
Locus: Xp22.12
Gene Diseases
The RPS6KA3 BMX Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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