RPS6KA1-LIN28A Fusion FISH Probe
The RPS6KA1-LIN28A Fusion FISH Probe is used to confirm a fusion of the RPS6KA1 and LIN28A genes. The fusion of the RPS6KA1 and LIN28A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPS6KA1-LIN28A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-RERE | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-REOR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-REGO | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-REGR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-REAQ | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-ORRE | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-OROR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-ORGO | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GORE | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GOOR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GOGO | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GOGR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GRRE | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GROR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GRGO | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GRGR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-AQRE | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-AQOR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-AQGO | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-AQGR | 20 (40 μL) | 200 μL |
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| RPS6KA1-LIN28A-20-AQAQ | 20 (40 μL) | 200 μL |
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RPS6KA1 Gene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein S6 Kinase A1
Chromosome: CHR1: 26856248 -26901520
Locus: 1p36.11
LIN28A Gene Summary
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]
Gene Name: Lin-28 Homolog A
Chromosome: CHR1: 26737268 -26756219
Locus: 1p36.11
Gene Diseases
The RPS6KA1 LIN28A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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