RPS6-OAZ1 Fusion FISH Probe
The RPS6-OAZ1 Fusion FISH Probe is used to confirm a fusion of the RPS6 and OAZ1 genes. The fusion of the RPS6 and OAZ1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPS6-OAZ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-RERE | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-REOR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-REGO | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-REGR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-REAQ | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-ORRE | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-OROR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-ORGO | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GORE | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GOOR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GOGO | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GOGR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GRRE | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GROR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GRGO | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GRGR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-AQRE | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-AQOR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-AQGO | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-AQGR | 20 (40 μL) | 200 μL |
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| RPS6-OAZ1-20-AQAQ | 20 (40 μL) | 200 μL |
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OAZ1 Gene Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Gene Name: Ornithine Decarboxylase Antizyme 1
Chromosome: CHR19: 2269519 -2273487
Locus: 19p13.3
RPS6 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein S6
Chromosome: CHR9: 19376253 -19380235
Locus: 9p22.1
Gene Diseases
The RPS6 OAZ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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