RPS5-DDX21 Fusion FISH Probe
The RPS5-DDX21 Fusion FISH Probe is used to confirm a fusion of the RPS5 and DDX21 genes. The fusion of the RPS5 and DDX21 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPS5-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| RPS5-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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RPS5 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein S5
Chromosome: CHR19: 58898635 -58906171
Locus: 19q13.43
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The RPS5 DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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